期刊
JOURNAL OF VIRAL HEPATITIS
卷 19, 期 5, 页码 364-370出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2893.2011.01558.x
关键词
hepatitis C virus; interferon; lignan; Swietenia macrophylla
资金
- National Science Council of Taiwan [NSC 100-2311-B-037-001]
- Council of Agriculture, Executive Yuan, Taiwan [100AS-1.1.5-HI-H3]
Chronic hepatitis C virus (HCV) infection ultimately leads to chronic hepatitis, hepatic cirrhosis and hepatocellular carcinoma (HCC). As the standard treatment is not completely efficacious, a safer and more effective agent against HCV infection needs to be developed. In this report, we demonstrated that 3-hydroxy caruilignan C (3-HCL-C) isolated from Swietenia macrophylla stems exhibited high anti-HCV activity at both protein and RNA levels at nontoxic concentrations, with an EC50 value of 10.5 +/- 1.2 mu m. Combinations of 3-HCL-C and interferon-a (IFN-a), an HCV NS5B polymerase inhibitor (2'-C-methylcytidine; NM-107) or an HCV NS3/4A protease inhibitor (Telaprevir; VX-950) increased the suppression of HCV RNA replication. The results suggested that 3-HCL-C may be a potential anti-viral agent. We then demonstrated that 3-HCL-C interfered with HCV replication by inducing IFN-stimulated response element transcription and IFN-dependent anti-viral gene expression.
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