期刊
JOURNAL OF VIRAL HEPATITIS
卷 15, 期 12, 页码 849-854出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2893.2008.01051.x
关键词
hepatitis C; hepatocyte; internalization; lipoproteins; receptors
资金
- NIAID PHS [AI50798, AA140034]
- Medical Research Council and The Wellcome Trust
- Medical Research Council [G9818340B, G0400802] Funding Source: researchfish
- MRC [G0400802] Funding Source: UKRI
Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.
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