期刊
JOURNAL OF VETERINARY SCIENCE
卷 15, 期 1, 页码 141-148出版社
KOREAN SOC VETERINARY SCIENCE
DOI: 10.4142/jvs.2014.15.1.141
关键词
alcohol; antioxidant capacity; betulinic acid; lipid peroxidation; liver damage
资金
- National Natural Science Foundation of China [31201964]
- Research Fund for the Doctoral Program of Higher Education of China [20124320120011]
- Department of Education of Hunan Province, China [12A066]
- Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization of China [12KFXM08]
Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential mechanism underlying the ability of this compound to prevent liver damage induced by alcohol in vivo. Mice were given oral doses of BA (0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and induced liver injury by feeding 50% alcohol orally at the dosage of 10 ml/kg after 1 h last administration of BA. BA pretreatment significantly reduced the serum levels of alanine transaminase, aspartate transaminase, total cholesterol, and triacylglycerides in a dose-dependent manner in the mice administered alcohol. Hepatic levels of glutathione, superoxide dismutase, glutathione peroxidase, and catalase were remarkably increased, while malondialdehyde contents and microvesicular steatosis in the liver were decreased by BA in a dose-dependent manner after alcohol-induced liver injury. These findings suggest that the mechanism underlying the hepatoprotective effects of BA might be due to increased antioxidant capacity, mainly through improvement of the tissue redox system, maintenance of the antioxidant system, and decreased lipid peroxidation in the liver.
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