期刊
JOURNAL OF VETERINARY SCIENCE
卷 14, 期 4, 页码 495-497出版社
KOREAN SOC VETERINARY SCIENCE
DOI: 10.4142/jvs.2013.14.4.495
关键词
dog; fibrocartilaginous embolic myelopathy; human umbilical cord-derived mesenchymal stem cells; percutaneous transplantation; xenotransplantaion
资金
- Konkuk University
The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cord of a dog suspected to have fibrocartilaginous embolic myelopathy (FCEM) and that experienced a loss of deep pain sensation. Locomotor functions improved following transplantation in a dog. Based on our findings, we suggest that transplantation of hUCB-derived MSCs will have beneficial therapeutic effects on FCEM patients lacking deep pain sensation.
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