期刊
JOURNAL OF VETERINARY SCIENCE
卷 13, 期 1, 页码 1-6出版社
KOREAN SOC VETERINARY SCIENCE
DOI: 10.4142/jvs.2012.13.1.1
关键词
fast neutron; hippocampus; learning and memory; neurogenesis
资金
- National Research Foundation (NRF) of Korea [2010-0017537]
- Korean government
- Korean Ministry of Education, Science, and Technology
- Biohousing Research Center
- Animal Medical Institute, Korea
Object recognition memory and contextual fear conditioning task performance in adult C578L/6 mice exposed to cranial fast neutron irradiation (0.8 Gy) were examined to evaluate hippocampus-related behavioral dysfunction following acute exposure to relatively low doses of fast neutrons. In addition, hippocampal neurogenesis changes in adult murine brain after cranial irradiation were analyzed using the neurogenesis immunohistochemical markers Ki-67 and doublecortin (DCX). In the object recognition memory test and contextual fear conditioning, mice trained 1 and 7 days after irradiation displayed significant memory deficits compared to the sham-irradiated controls. The number of Ki-67- and DCX-positive cells decreased significantly 24 h post-irradiation. These results indicate that acute exposure of the adult mouse brain to a relatively low dose of fast neutrons interrupts hippocampal functions, including learning and memory, possibly by inhibiting neurogenesis.
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