期刊
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
卷 36, 期 5, 页码 494-501出版社
WILEY
DOI: 10.1111/jvp.12020
关键词
-
资金
- National Natural Science Foundation of China [090600253]
Drug-drug interactions (DDIs) may adversely affect the prevention and cure of diseases. The effects of three polyether ionophore antibiotics, salinomycin (SAL), monensin (MON), and maduramycin (MAD) on the pharmacokinetics of florfenicol (FFC) were investigated in broilers. The chickens were fed rations with or without SAL (60mg/kg feeds), MON (120mg/kg feeds), or MAD (5mg/kg feeds) for 14 consecutive days. FFC was given to the chickens either intravenously (i.v.) or orally (p.o.) at a single dose of 30mg/kg body weight. Blood samples were taken from each chicken at 0-24h postadministration of FFC. The plasma concentration of FFC was detected by high-performance liquid chromatography. The plasma concentration of FFC decreased with i.v. or p.o. co-administration of SAL, MON, or MAD in broilers, implying occurrence of DDIs during the co-administration of FFC with these ionophores. Our findings suggest that more attention should be given to the use of FFC to treat bacterial infections in chickens supplemented with polyether ionophore antibiotics.
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