期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 76, 期 10, 页码 1407-1410出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.13-0635
关键词
canine; colon; cytokine; lymphocytic-plasmacytic colitis; mRNA
资金
- Japan Society for the Promotion of Science [23780315]
- Grants-in-Aid for Scientific Research [23780315] Funding Source: KAKEN
Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-gamma, IL-4, IL-17 and IL-10 and pro-inflammatory cytokines, such as IL-1 beta, IL-6, TNF-alpha., IL-8, IL-12 and IL-23, in colonic mucosa from LPC dogs by quantitative real-time RT-PCR. No significant differences were detected in cytokine mRNA expressions between dogs with LPC and controls, except for IL-23p19. Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD.
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