期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 71, 期 10, 页码 1357-1363出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.001357
关键词
HFRS; Rattus; rodent; Seoul virus; zoonosis
资金
- Founding Research Centers for Emerging and Reemerging Infectious Diseases, MEXT, Japan
- 21st Century COE Program, Program of Excellence for Zoonosis Control
- Japanese Ministry of Education, Culture, Sports, Science and Technology, Japan
The distribution of anti-hantavirus antibodies in humans and rodents in northern Vietnam was examined. In total, 837 seruml samples from healthy humans (617) and patients with fever (220), living in six different areas were screened for IgG antibodies against Hantaan or Seoul virus (SEOV) by ELISA, IFA, and Western blot analysis. Antibody-positive sera were identified ill 7/617 (1.1%) healthy donors, 51150 port workers in the port of Hai Phong, and 2/185 residents of Ha Nam Province. In comparison, positive sera were detected in 5/220 (2.3%) fever patients ill the provinces of Ha Nam (1/58) and Thanh Hoa (4/146). Antibody-positive Rattus norvegicus were found in the provinces of Ha Nam (7/52) and Thanh Hoa (1/67), in Haibatrung District (7/43) in Hanoi, and in Hai Phong Port (21/62), while antibody-positive R. rattus (2/17) were found in Hai Phong Port. Part of the Gc region from the viral genome was amplified by RT-PCR using lung tissue samples front R. norvegicus in Haibatrung (2/7) and Hai Phong Port (7/9), bill not from R. rattus (0/2). Viral sequences were located in the SEOV clade and formed a single lineage with Indonesian SEOV. suggesting that Vietnamese SEOV is part of a distinct lineage among Asian SEOVs.
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