期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 70, 期 3, 页码 313-315出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.70.313
关键词
blood-cerebrospinal fluid barrier; lactoferrin; transcytosis
The transportation of intravenously administered bovine lactoferrin (bLF) into the cerebrospinal fluid (CSF) was immunohistochemically investigated in adult rats. Administered bLF was detected in the vesicular membranes of endothelial cells in cerebral blood vessels 10 min after the infusion. Numerous immunoreactive small vesicles were also detected at the ependymal cells in the choroid plexus. Moreover, the bLF concentration in the CSF was significantly increased at 1-2 hr after the intravenous infusion of bLF (10 or 30 mg/kg). These findings clearly demonstrate that LF is possibly transported into the brain matter even in adult animals.
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