期刊
PROCESS BIOCHEMISTRY
卷 50, 期 1, 页码 134-139出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2014.10.017
关键词
Destruxin B; Helicobacter pylori; Vacuolating cytotoxin A; V-ATPase
资金
- Ministry of Science and Technology, Taiwan [102-2811-M-324-001, 101-2313-B-039-004-MY3, 103-2633-B-039-001]
- China Medical University [CMU102-BC-2]
- Clinical Trial and Research Center of Excellence Funds from the Taiwan Ministry of Health and Welfare [MOHW103-TD-B-111-03]
- Tomorrow Medicine Foundation
Infection with Helicobacter pylori in the gastric mucosa is thought to be increased the risk of peptic ulcer disease and gastric cancer. Vacuolating cytotoxin A (VacA) was an important bacterial virulence factor and was closely associated with Helicobacter pylori-induced pathogenesis. Upon Helicobacter pylori infection, the VacA can be transferred directly from bacteria into the host cells where can stimulate vacuolar-type ATPase (V-ATPase) proton pump and induce the formation of vacuoles in gastric epithelial cells followed by intoxication of cells. Destruxin B (Dtx-B), a cyclodepsipeptide from the fungus Metarhizium anisopliae bearing insecticidal and anticancer effects. In this study, Dtx-B demonstrated inhibitory effects against Helicobacter pylori VacA-induced vacuolization in gastric epithelial cells. Our data further showed that attenuation of Helicobacter pylori-induced vacuolization in gastric epithelial cells by Dtx-B is mediated through inhibition of V-ATPase activity rather than VacA expression levels. The results from this study reveal a novel role for Dtx-B in the modulation of Helicobacter pylori VacA-induced pathogenesis. (C) 2014 Elsevier Ltd. All rights reserved.
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