期刊
JOURNAL OF VASCULAR RESEARCH
卷 50, 期 2, 页码 89-99出版社
KARGER
DOI: 10.1159/000345243
关键词
Arteries; Vascular stiffness; Remodeling; Vasoconstriction; Endothelial dysfunction; Inflammation; Oxidative stress; Genomic and nongenomic effects
资金
- Canadian Institutes of Health Research (CIHR) [37917, 82790, 102606]
- Canada Research Chair on Hypertension and Vascular Research from CIHR/Government of Canada
- Canada Fund for Innovation
- Heart and Stroke Foundation of Canada
Aldosterone exerts direct effects on the vascular system by inducing oxidative stress, inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone exerts its effects through genomic and nongenomic pathways in a mineralocorticoid receptor (MR)-dependent or independent manner. Other aldosterone receptors such as GPR30 have been identified. A tight relation exists between the aldosterone and angiotensin II pathways, as well as with the endothelin-1 system. There is a correlation between plasma levels of aldosterone and cardiovascular risk. Recently, an increasing body of evidence has underlined the importance of aldosterone in cardiovascular complications associated with the metabolic syndrome, such as arterial remodeling and endothelial dysfunction. Blockade of MR is an increasingly used evidence-based therapy for many forms of cardiovascular disease, including hypertension, heart failure, chronic kidney disease, and diabetes mellitus. Copyright (c) 2012 S. Karger AG, Basel
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