期刊
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
卷 24, 期 8, 页码 1201-1207出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jvir.2013.03.034
关键词
-
资金
- Defense for Research and Engineering under Air Force Contract [FA8721-05-C-0002]
Although much attention has been paid to mechanisms of anticancer drug resistance that focus. on intracellular processes that,. protect tumor cells, it has recently become increasingly evident that the unique features of the tumor microenvironment profoundly impact the efficacy of cancer therapies. The properties of this extracellular milieu, including increased interstitial pressure, decreased pH, hypoxia, and abnormal vascularity, result in limited drug efficacy; this finding is true not only for systemic chemotherapy but also for catheter-based therapies, including chemoembolization and radioembolization. The present review summarizes the bathers to drug delivery imposed by the tumor microenvironment and provides methods' to overcome these hurdles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据