期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 45, 页码 13970-13975出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1515937112
关键词
social evolution; phenotypic plasticity; genome sequencing; transcriptomes; DNA methylation
资金
- Natural Environment Research Council [NE/G000638/1, NBAF581, NE/K011316/1, NE/G012121/1]
- Research Councils UK
- Cancer Research UK [C14303/A17197]
- Leverhulme Trust
- German Federal Ministry of Education and Research Grant FKZ [0315962 B]
- CRG core funding
- Spanish Ministry of Economy and Competitiveness (MINECO) [BIO2012-37161]
- MINECO [BIO2011-26205]
- Institut de Salud Carlos III [PT13/0001/0021]
- Institut Nacional de Bioinformatica and Agencia de Gestio d'Ajuts Universitaris i de Recerca
- Wellcome Trust [095645/Z/11/Z, WT099232]
- Biotechnology and Biological Sciences Research Council [BB/K010867/1]
- Stuttgart Universitat
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo Grant [2010/10027-5]
- ICREA Funding Source: Custom
- BBSRC [BBS/E/B/0000H334, BBS/E/B/000C0403] Funding Source: UKRI
- MRC [G0801156] Funding Source: UKRI
- NERC [NE/K011316/1, NE/G000638/1, NE/G012121/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000H334, BBS/E/B/000C0403] Funding Source: researchfish
- Medical Research Council [G0801156] Funding Source: researchfish
- Natural Environment Research Council [NE/G000638/1, NE/K011316/1] Funding Source: researchfish
Phenotypic plasticity is important in adaptation and shapes the evolution of organisms. However, we understand little about what aspects of the genome are important in facilitating plasticity. Eusocial insect societies produce plastic phenotypes from the same genome, as reproductives (queens) and nonreproductives (workers). The greatest plasticity is found in the simple eusocial insect societies in which individuals retain the ability to switch between reproductive and nonreproductive phenotypes as adults. We lack comprehensive data on the molecular basis of plastic phenotypes. Here, we sequenced genomes, microRNAs (miRNAs), and multiple transcriptomes and methylomes from individual brains in a wasp (Polistes canadensis) and an ant (Dinoponera quadriceps) that live in simple eusocial societies. In both species, we found few differences between phenotypes at the transcriptional level, with little functional specialization, and no evidence that phenotype-specific gene expression is driven by DNA methylation or miRNAs. Instead, phenotypic differentiation was defined more subtly by nonrandom transcriptional network organization, with roles in these networks for both conserved and taxon-restricted genes. The general lack of highly methylated regions or methylome patterning in both species may be an important mechanism for achieving plasticity among phenotypes during adulthood. These findings define previously unidentified hypotheses on the genomic processes that facilitate plasticity and suggest that the molecular hallmarks of social behavior are likely to differ with the level of social complexity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据