期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 20, 页码 E2695-E2704出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1410767112
关键词
orbitofrontal cortex; anterior cingulate cortex; decision making; resting state functional connectivity; comparative anatomy
资金
- Medical Research Council UK
- Christopher Welsh scholarship at the University of Oxford
- Netherlands Organisation for Scientific Research fellowship from the Dutch Organization for Scientific Research
- Wellcome Trust
- Medical Research Council [G0902373, G0400593, G0700399] Funding Source: researchfish
- Wellcome Trust [101092/Z/13/Z, 100973/Z/13/Z] Funding Source: researchfish
- MRC [G0400593, G0700399, G0902373] Funding Source: UKRI
- Wellcome Trust [100973/Z/13/Z] Funding Source: Wellcome Trust
Reward-guided decision-making depends on a network of brain regions. Among these are the orbitofrontal and the anterior cingulate cortex. However, it is difficult to ascertain if these areas constitute anatomical and functional unities, and how these areas correspond between monkeys and humans. To address these questions we looked at connectivity profiles of these areas using resting-state functional MRI in 38 humans and 25 macaque monkeys. We sought brain regions in the macaque that resembled 10 human areas identified with decision making and brain regions in the human that resembled six macaque areas identified with decision making. We also used diffusion-weighted MRI to delineate key human orbital and medial frontal brain regions. We identified 21 different regions, many of which could be linked to particular aspects of reward-guided learning, valuation, and decision making, and in many cases we identified areas in the macaque with similar coupling profiles.
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