期刊
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
卷 23, 期 1, 页码 33-39出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jvir.2011.09.010
关键词
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资金
- American College of Phlebology
- British Heart Foundation [FS/08/002/24537] Funding Source: researchfish
Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.
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