期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 30, 页码 9484-9489出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1508545112
关键词
adult neurogenesis; lineage tracing; migration; hippocampus; vascular niche
资金
- NIH [NS048271, MH105128, NS047344]
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Swiss National Science Foundation [PP00A-119026/1]
- Foundation Leenaards
- Children's Tumor Foundation
In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit significant tangential migration along blood vessels, followed by limited radial migration. Genetic birthdating and morphological and molecular analyses pinpointed the neuroblast stage as the main developmental window when tangential migration occurs. We also developed a partial whole-mount dentate gyrus preparation and observed a dense plexus of capillaries, with which only neuroblasts, among the entire population of progenitors, are directly associated. Together, these results provide insight into neuronal migration in the adult mammalian nervous system.
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