期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 34, 页码 10617-10622出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1508599112
关键词
polymers; automation; continuous flow chemistry; unimolecular macromolecules; sequence-controlled polymers
资金
- National Science Foundation Science, Engineering and Education for Sustainability (SEES) postdoctoral fellowship
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1314022, 1655581] Funding Source: National Science Foundation
We report a semiautomated synthesis of sequence and architecturally defined, unimolecular macromolecules through a marriage of multistep flow synthesis and iterative exponential growth (Flow-IEG). The Flow-IEG system performs three reactions and an in-line purification in a total residence time of under 10 min, effectively doubling the molecular weight of an oligomeric species in an uninterrupted reaction sequence. Further iterations using the Flow-IEG system enable an exponential increase in molecular weight. Incorporating a variety of monomer structures and branching units provides control over polymer sequence and architecture. The synthesis of a uniform macromolecule with a molecular weight of 4,023 g/mol is demonstrated. The user-friendly nature, scalability, and modularity of Flow-IEG provide a general strategy for the automated synthesis of sequence-defined, unimolecular macromolecules. Flow-IEG is thus an enabling tool for theory validation, structure-property studies, and advanced applications in biotechnology and materials science.
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