期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 16, 页码 4871-4876出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1403665112
关键词
fossil record; development; genomics; evolution; limb
资金
- Graduate Assistance in Areas of National Need Grant [P200A120178]
- National Institutes of Health Grant [T32 HD055164]
- National Science Foundation Doctoral Dissertation Improvement Grant [1311436]
- Uehara Memorial Foundation Research Fellowship
- Japan Society for the Promotion of Science Postdoctoral Research Fellowship [2012-127]
- Marine Biological Laboratory Research Award
- Brazilian National Council for Scientific and Technological Development (CNPq) [402754/2012-3, 477658/2012-1]
- Brinson Foundation
- University of Chicago Biological Sciences Division
- Direct For Biological Sciences
- Division Of Environmental Biology [1311436] Funding Source: National Science Foundation
The fossil record is a unique repository of information on major morphological transitions. Increasingly, developmental, embryological, and functional genomic approaches have also conspired to reveal evolutionary trajectory of phenotypic shifts. Here, we use the vertebrate appendage to demonstrate how these disciplines can mutually reinforce each other to facilitate the generation and testing of hypotheses of morphological evolution. We discuss classical theories on the origins of paired fins, recent data on regulatory modulations of fish fins and tetrapod limbs, and case studies exploring the mechanisms of digit loss in tetrapods. We envision an era of research in which the deep history of morphological evolution can be revealed by integrating fossils of transitional forms with direct experimentation in the laboratory via genome manipulation, thereby shedding light on the relationship between genes, developmental processes, and the evolving phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据