期刊
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
卷 40, 期 12, 页码 1242-1252出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/apnm-2015-0141
关键词
metabolic syndrome; nonalcoholic fatty liver disease; aerobic interval training; aerobic capacity; lipid metabolism; hepatic metabolic pathways; liver antioxidant status
资金
- Junta de Andalucia, Spain [P09-AGR-4658]
- Institute for Health and Wellbeing Research
- European Union [AGL2013-43247-R]
Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old) followed a protocol of AIT (4 min at 65%-80% of maximal oxygen uptake, followed by 3 min at 50%-65% of maximal oxygen uptake for 45-60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats had higher food intake and body weight (P < 0.0001) and suffered significant alterations in plasma lipid profile, area under the curve after oral glucose overload (P < 0.0001), liver histology and functionality, and antioxidant status. The AIT protocol reduced the severity of alterations related to glucose and lipid metabolism and increased the liver protein expression of PPAR gamma, as well as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS.
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