期刊
JOURNAL OF UROLOGY
卷 190, 期 3, 页码 1102-1109出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.juro.2013.02.3229
关键词
urinary bladder; gastric bypass; obesity, morbid; calcium oxalate; steatorrhea
资金
- National Institutes of Health [K08 DK089000-03]
- American Urological Association Care Foundation Rising Star in Urology Research Award
- Astellas Global Development, Inc.
- Ethicon Endo-Surgery
Purpose: We determined the effect of dietary fat and oxalate on fecal fat excretion and urine parameters in a rat model of Roux-en-Y gastric bypass surgery. Materials and Methods: Diet induced obese Sprague-Dawley (R) rats underwent sham surgery as controls (16), or Roux-en-Y gastric bypass surgery (19). After recovery, rats had free access to a normal calcium, high fat (40%) diet with or without 1.5% potassium oxalate for 5 weeks and then a normal (10%) fat diet for 2 weeks. Stool and urine were collected after each period. Fecal fat was determined by gas chromatography and urine metabolites were evaluated by assay spectrophotometry. Results: Daily fecal fat excretion remained low in controls on either diet. However, Roux-en-Y gastric bypass rats ingested a food quantity similar to that of controls but had eightfold higher fecal fat excretion (p < 0.001) and heavier stools (p = 0.02). Compared to controls, gastric bypass rats on the high fat diet with potassium oxalate had a fivefold increase in urine oxalate excretion (p < 0.001), while gastric bypass rats without potassium oxalate had a twofold increase in urine calcium (p < 0.01). Lowering dietary fat in gastric bypass rats with potassium oxalate led to a 50% decrease in oxalate excretion (p < 0.01), a 30% decrease in urine calcium and a 0.3 U increase in urine pH (p < 0.001). Conclusions: In this Roux-en-Y gastric bypass model high fat feeding resulted in steatorrhea, hyperoxaluria and low urine pH, which were partially reversible by lowering the dietary fat and oxalate content. Roux-en-Y gastric bypass rats on normal fat and no oxalate diets excreted twice as much oxalate as age matched, sham operated controls. Although Roux-en-Y gastric bypass hyperoxaluria appears primarily mediated by gut and diet, secondary causes of oxalogenesis from liver or other mechanisms deserve further exploration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据