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Jeffrey A. Engelman et al.
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Helen Y. Zou et al.
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Al Charest et al.
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Oncogenic pathway signatures in human cancers as a guide to targeted therapies
AH Bild et al.
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DE Mager et al.
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Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
A Charest et al.
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A Bhattacharjee et al.
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ME Garber et al.
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DR Robinson et al.
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