期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 25, 页码 7695-7700出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1417071112
关键词
cytochrome c oxidase; sodium pumping; cbb(3)-type oxidase; alkaliphily
资金
- European Research Council [PARASOL 322551]
- Russian Foundation for Basic Research [14-04-01577, 05-04-49504, 13-04-40405]
- Russian Scientific Fund Grant [14-50-00029]
Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb(3) cytochromes), which are widespread among pathogenic bacteria, are the least understood. In particular, the proton-pumping machinery of these Coxs has not yet been elucidated despite the availability of X-ray structure information. Here, we report the discovery of the first (to our knowledge) sodium-pumping Cox (Scox), a cbb(3) cytochrome from the extremely alkaliphilic bacterium Thioalkalivibrio versutus. This finding offers clues to the previously unknown structure of the ion-pumping channel in the C-type Coxs and provides insight into the functional properties of this enzyme.
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