期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 4, 页码 1220-1225出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1412996112
关键词
interneurons; synaptic transmission; dentate gyrus; basket cell; gamma oscillations
资金
- Lichtenberg Award (Volkswagenstiftung)
- Schram Foundation
- Brain-Links Brain-Tools, Cluster of Excellence - Deutsche Forschungsgemeinschaft [EXC 1086]
- German Research Foundation [DFG BA 1582/2-1, FOR2143]
- Excellence Initiative, GSC-4, Spemann Graduate School
- Scottish Universities Life Sciences Alliance
- Fond zur Forderung der Wissenschaftlichen Forschung [P 24909-B24]
- European Union (European Research Council) [268548]
- Austrian Science Fund (FWF) [P24909] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 24909] Funding Source: researchfish
GABAergic perisoma-inhibiting fast-spiking interneurons (PIIs) effectively control the activity of large neuron populations by their wide axonal arborizations. It is generally assumed that the output of one PII to its target cells is strong and rapid. Here, we show that, unexpectedly, both strength and time course of PII-mediated perisomatic inhibition change with distance between synaptically connected partners in the rodent hippocampus. Synaptic signals become weaker due to lower contact numbers and decay more slowly with distance, very likely resulting from changes in GABA(A) receptor subunit composition. When distance-dependent synaptic inhibition is introduced to a rhythmically active neuronal network model, randomly driven principal cell assemblies are strongly synchronized by the PIIs, leading to higher precision in principal cell spike times than in a network with uniform synaptic inhibition.
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