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注意:仅列出部分参考文献,下载原文获取全部文献信息。Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization
Jeronimo Lameira et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2015)
Linking Electrostatic Effects and Protein Motions in Enzymatic Catalysis. A Theoretical Analysis of Catechol O-Methyltransferase
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JOURNAL OF PHYSICAL CHEMISTRY B (2015)
Picosecond-Resolved Fluorescent Probes at Functionally Distinct Tryptophans within a Thermophilic Alcohol Dehydrogenase: Relationship of Temperature-Dependent Changes in Fluorescence to Catalysis
Corey W. Meadows et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2014)
Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C-H Activation
Shenshen Hu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Importance of Protein Dynamics during Enzymatic C-H Bond Cleavage Catalysis
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BIOCHEMISTRY (2013)
Conservation and Functional Importance of Carbon-Oxygen Hydrogen Bonding in Ado Met-Dependent Methyltransferases
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Current Chemical Biology Approaches to Interrogate Protein Methyltransferases
Minkui Luo
ACS CHEMICAL BIOLOGY (2012)
S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications
Anna-Winona Struck et al.
CHEMBIOCHEM (2012)
A Systematic Review of Catechol-O-Methyltransferase Inhibitors: Efficacy and Safety in Clinical Practice
Sandro Zambito Marsala et al.
CLINICAL NEUROPHARMACOLOGY (2012)
Architectures, mechanisms and molecular evolution of natural product methyltransferases
David K. Liscombe et al.
NATURAL PRODUCT REPORTS (2012)
Good vibrations in enzyme-catalysed reactions
Sam Hay et al.
NATURE CHEMISTRY (2012)
Taking Ockham's razor to enzyme dynamics and catalysis
David R. Glowacki et al.
NATURE CHEMISTRY (2012)
Direct Evidence for Methyl Group Coordination by Carbon-Oxygen Hydrogen Bonds in the Lysine Methyltransferase SET7/9
Scott Horowitz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Enzymatic Methyl Transfer: Role of an Active Site Residue in Generating Active Site Compaction That Correlates with Catalytic Efficiency
Jianyu Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Investigations of enzyme-catalysed reactions with combined quantum mechanics/molecular mechanics (QM/MM) methods
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INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY (2010)
QM/MM Methods for Biomolecular Systems
Hans Martin Senn et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Enzymatic transition states and dynamic motion in barrier crossing
Steven D. Schwartz et al.
NATURE CHEMICAL BIOLOGY (2009)
A 21st century revisionist's view at a turning point in enzymology
Zachary D. Nagel et al.
NATURE CHEMICAL BIOLOGY (2009)
Protein methyltransferases as a target class for drug discovery
Robert A. Copeland et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
QM/MM simulations for methyl transfer in solution and catalysed by COMT: ensemble-averaging of kinetic isotope effects
Natalia Kanaan et al.
CHEMICAL COMMUNICATIONS (2008)
A new tool for biotechnology: AdoMet-dependent methyltransferases
Saulius Klimasauskas et al.
TRENDS IN BIOTECHNOLOGY (2007)
Tunneling and dynamics in enzymatic hydride transfer
Zachary D. Nagel et al.
CHEMICAL REVIEWS (2006)
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
F Lyko et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)
QM/MM determination of kinetic isotope effects for COMT-catalyzed methyl transfer does not support compression hypothesis
GD Ruggiero et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Theoretical modeling of enzyme catalytic power:: Analysis of cratic and electrostatic factors in catechol O-methyltransferase
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
QM-FE and molecular dynamics calculations on catechol O-methyltransferase:: Free energy of activation in the enzyme and in aqueous solution and regioselectivity of the enzyme-catalyzed reaction
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Transition-state and ground-state structures and their interaction with the active-site residues in catechol O-methyltransferase
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)