期刊
JOURNAL OF TROPICAL PEDIATRICS
卷 58, 期 3, 页码 208-213出版社
OXFORD UNIV PRESS
DOI: 10.1093/tropej/fmr068
关键词
Helicobacter pylori; acquisition; infants; prospective cohort; stool; risk factors
资金
- Israel Ministry of Health [1-6159]
- Israel Ministry of Science and Technology
- Dan David Foundation
We examined the age of acquisition of Helicobacter pylori infection in a prospective study that was conducted among 231 Israeli Arab children. Helicobacter pylori was identified in stool specimens collected at ages 2, 4, 6, 8, 12 and 18 months, using a monoclonal stool antigen immunoassay. Information on household characteristics, breastfeeding, antibiotic use and hygiene practices was obtained. The incidence of H. pylori infection was 33.3%. The estimated mean age of H. pylori infection acquisition was 14 months. The determinants of H. pylori infection were living in a low socioeconomic status (SES) village: OR 9.60 (95% CI 2.91-31.68, p < 0.001); low paternal education: OR 3.35 (95% CI 1.21-9.29, p = 0.02); and boiling feeding bottles and nipples at low frequency: OR 7.12 (95% CI 1.82-27.86, p = 0.005). In conclusion, H. pylori infection is acquired at a higher rate in low SES settings. Parental education and hygiene play an important role in H. pylori acquisition in infancy.
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