Haplotype of IL-8-251T and 781C is associated with the Susceptibility to Respiratory Syncytial Virus

Methods: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele's frequencies of SNPs were analyzed with case-control study, linkage of two loci and haplotypes composed by the two loci were also studied. Results: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01). Conclusion: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.