期刊
JOURNAL OF TRANSLATIONAL MEDICINE
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1479-5876-8-100
关键词
-
资金
- NIH [RO1 CA121258, CA125244, CA154256, K01 CA111402, R01CA123396, R01 CA112358, CA121131]
- CBCRP [14IB-0045]
- DOD CDMRP [W81XWH-01-1-0734]
Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still poor. A small contingent of clinical researchers are focusing their efforts on testing the safety, feasibility and efficacy of experimental active and passive immunotherapy approaches for gliomas and are primarily conducting Phase I and II clinical trials. Few trials have advanced to the Phase III arena. Here we provide an overview of the cellular therapies and vaccine trials currently open for patient accrual obtained from a search of http://www.clinicaltrials.gov. The search was refined with terms that would identify the Phase I, II and III immunotherapy trials open for adult glioma patient accrual in the United States. From the list, those that are currently open for patient accrual are discussed in this review. A variety of adoptive immunotherapy trials using ex vivo activated effector cell preparations, cell-based and non-cell-based vaccines, and several combination passive and active immunotherapy approaches are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据