期刊
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
卷 27, 期 2, 页码 154-159出版社
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2012.09.003
关键词
Se-methylselenocysteine (MSC); Ionizing radiation; Oxidative stress; Antioxidants; Glutathione
资金
- University of Incheon Research Grant
We investigated the preventive effect of Se-methylselenocysteine (MSC) administration on gamma-radiation (whole body irradiation, single 10-Gy dose)-induced oxidative damage in rat lungs. Rats were pre-treated with MSC (0.75 mg/rat/day) for 1 week before gamma-irradiation. The MSC pretreatment prevented the irradiation-induced increase in lipid peroxidation and the concomitant decrease in cellular glutathione content. The prevention of irradiation-induced oxidative damage in MSC-pretreated rat lungs appeared to be associated with increased antioxidant capacity, particularly in the glutathione system. The 1-week MSC treatment resulted in an increase in glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase activities, which are involved in glutathione redox cycling. An increase in catalase activity was also observed in the rat lungs. Additionally, a significantly increased level of nuclear factor erythroid 2-related factor 2 (Nrf2) was exhibited in the MSC-treated rat lungs. Heme oxygenase 1, glutathione S-transferase pi, and peroxiredoxin 1, which are known target proteins of Nrf2, were also increased in MSC-treated lungs. These results implicate Nrf2 signaling in the MSC-induced activation of the antioxidant system. (C) 2012 Elsevier GmbH. All rights reserved.
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