期刊
JOURNAL OF TOXICOLOGICAL SCIENCES
卷 36, 期 3, 页码 389-391出版社
JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.36.389
关键词
Methylmercury; Gene expression; Mice; Cerebellum; Chemokines
类别
资金
- Grants-in-Aid for Scientific Research [19101003] Funding Source: KAKEN
To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encoding proteins involved in inflammatory reactions associated with chemokines. The expression levels of 11 genes were reduced by half or more in response to methylmercury.
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