期刊
JOURNAL OF TOXICOLOGICAL SCIENCES
卷 34, 期 3, 页码 349-354出版社
JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.34.349
关键词
FePt nanoparticle; 2-aminoethanethiol; Cysteamine; Genotoxicity; Bacterial reverse mutation assay; Chromosomal aberration test
类别
资金
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
Genotoxicity of superparamagnetic iron-platinum (Feet) nanoparticles (NPs) capped with 2-aminoethanethiol (AET) was evaluated using the bacterial reverse mutation assay (Ames test) and in vitro chromosomal aberration test. Mutagenicity of AET-capped FePt NPs was found to be negative in the Ames test, while elastogenicity of FePt NPs seemed to be false-positive in the in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells. However, further detailed in vitro genotoxicity tests, such as DNA adduct studies, are necessary to conclude that a positive aberration result is irrelevant.
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