期刊
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
卷 4, 期 5, 页码 349-355出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/term.245
关键词
bone morphogenetic protein; silk fibroin; microparticles; drug delivery; BMP-2; BMP-9; BMP-14
类别
资金
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/17049/2004]
- FEDER [POCI/CTM/57177/2004]
- Marie Curie Alea Jacta EST [MEST-CT-2004-8104]
- European STREP [NMP3-CT-2003-505758]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/17049/2004, POCI/CTM/57177/2004] Funding Source: FCT
Bone morphogenetic proteins (BMPs) are cytokines with strong ability to promote new bone formation. Herein, we report the use of silk fibroin microparticles as carriers for the delivery of BMP-2, BMP-9 or BMP-14. BMP-containing fibroin microparticles were prepared by a mild methodology using dropwise addition of ethanol, exhibiting mean diameters of 2.7 +/- 0.3 mu m. Encapsulation efficiencies varied between 67.9 +/- 6.1 % and 97.7 +/- 2.0 % depending on the type and the amount of BMP loaded. Release kinetics showed that BMP-2, BMP-9 and BMP-14 were released in two phases profile, with a burst release in the first two days followed by a slower release, for a period of 14 days. The release data were best explained by Korsmeyer's model and the Fickian model of drug diffusion. Silk fibroin microparticles can offer a promising approach for the sustained delivery of different BMPs in tissue engineering applications. Copyright (C) 2010 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据