期刊
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
卷 4, 期 7, 页码 543-552出版社
WILEY
DOI: 10.1002/term.271
关键词
rabbit; tibial fracture; biomechanics; periosteal callus; rhBMP-2; collagen
类别
资金
- Ministry of Science and Technology [BIO2009-13903-C02-01]
- Ministry of Health and Consumption [FIS PI06/1855]
- Ministry of Science and Innovation [PLE2009-0163]
- Red TerCel (Institute of Health Carlos III)
- Andalusian Autonomous Government [P07-CVI-2781, PAIDI BIO-217]
The utility of recombinant human bone morphogenetic protein-2 (rhBMP-2) in inducing bone formation in fractures of bone is well known. However, the influence of the mechanical environment on the actions of rhBMP-2 on fracture healing is not clear. An experimental model of fractures of the tibia in rabbits was developed and utilized to investigate the role of mechanical environment on rhBMP-2 action. A 1 mm osteotomy gap was stabilized by either a low-or high-stiffness fixator (LSF or HSF, respectively), and local treatment with rhBMP-2 in an absorbable collagen sponge (ACS) was evaluated. The results of the investigation were analysed by both histomorphometry and biomechanics. The LSF caused an increase in mineralized periosteal callus compared to HSF, the rhBMP-2 in ACS accelerated fracture healing only in the LSF group but not in the HSF group. The area of mineralized tissue in interfragmentary callus was determined by fixation stiffness and not by BMP treatment. rhBMP-2 caused higher bone resorption in the endosteal callus during the late stages of fracture healing, but these histological differences did not affect the mechanical properties. Biomechanical evaluation showed only differences at 3 weeks between LSF-rhBMP-2 and LSF-ACS. The bending and torsional properties were higher in the rhBMP-2/ACS group compared to ACS alone at 3 weeks. Copyright (C) 2010 John Wiley & Sons, Ltd.
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