期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 11, 期 1, 页码 2-16出版社
WILEY
DOI: 10.1111/jth.12045
关键词
coagulation factors; clot retraction; fibrin formation; platelet receptors; procoagulant activity; thrombin generation
资金
- Cardiovascular Centre (HVC) Maastricht
- Netherlands Heart Foundation [2011T006]
- Center for Translational Molecular Medicine (CTMM) INCOAG
. Platelets in a thrombus interact with (anti)coagulation factors and support blood coagulation. In the concept of cell-based control of coagulation, three different roles of platelets can be distinguished: control of thrombin generation, support of fibrin formation, and regulation of fibrin clot retraction. Here, we postulate that different populations of platelets with distinct surface properties are involved in these coagulant functions. Platelets with elevated Ca2+ and exposed phosphatidylserine control thrombin and fibrin generation, while platelets with activated aIIb beta 3 regulate clot retraction. We review how coagulation factor binding depends on the platelet activation state. Furthermore, we discuss the ligands, platelet receptors and downstream intracellular signaling pathways implicated in these coagulant functions. These insights lead to an adapted model of platelet-based coagulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据