期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 9, 期 -, 页码 162-167出版社
WILEY
DOI: 10.1111/j.1538-7836.2011.04300.x
关键词
Gla domains; membranes; phosphatidylserine; phospholipids
资金
- NIH [HL47014, GM75937, GM79530, RR025037, R01 GM086749, R01-GM067887, P41 RR-05969, HL103999]
- TeraGrid resources [MCA06N060]
Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.
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