期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 7, 期 -, 页码 35-37出版社
WILEY
DOI: 10.1111/j.1538-7836.2009.03424.x
关键词
angiogenesis; blood flow; nitric oxide; permeability; vasodilation
资金
- NHLBI NIH HHS [R01 HL061371, R01 HL057665, R01 HL096670] Funding Source: Medline
In the past decade, the importance of the vascular endothelium as a multifunctional regulator of vascular smooth muscle physiology and pathophysiology has been appreciated. Indeed, the endothelium responds to hemodynamic stimuli (pressure, shear stress and wall strain) and locally manufactured mediators (such as bradykinin, prostaglandins, angiotensin II and nitric oxide) that can influence blood flow, cell trafficking into tissue and angiogenesis. In this chapter, the importance of nitric oxide (NO) as a mediator of blood flow control, vascular permeability and angiogenesis will be discussed.
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