期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 6, 期 6, 页码 969-975出版社
WILEY
DOI: 10.1111/j.1538-7836.2008.02954.x
关键词
animal model; hemophilia; joint bleeding; murine; recombinant factor VIIa; recombinant factor VIII
Background: Hemophilia A is the most common serious bleeding disorder, and the hallmark of this disease is joint bleeding episodes. These result in hemophilic synovitis, an inflammatory and proliferative condition of the joint, which progresses into a chronic degenerative arthritis, hemophilic arthropathy. Methods: In this paper, we describe the effect of recombinant factor VIIa (rFVIIa), and an analogue NN1731 as well as rFVIII on needle-induced bleeding in hemophilia A mice. Conclusions: Here we show a reducing effect of rFVIIa and NN1731 on bleeding induced in hemophilic mice, and we show that preventive treatment with rFVIII normalizes bleeding.
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