期刊
JOURNAL OF THORACIC ONCOLOGY
卷 5, 期 2, 页码 153-157出版社
ELSEVIER SCIENCE INC
DOI: 10.1097/JTO.0b013e3181c8cc0c
关键词
Lung adenocarcinoma; Bronchioloalveolar carcinoma; Invasion; TGF-beta; TGF beta RII; RANTES; Lung cancer genomics
资金
- NCI NIH HHS [R01 CA120174, R01 CA120174-04] Funding Source: Medline
The histologic distinction between bronchioloalveolar carcinoma and other adenocarcinomas is tissue invasion. The clinical importance of lung adenocarcinoma invasion is supported by several recent Studies indicating that the risk of death in nonmucinous bronchioloalveolar carcinoma is significantly lower than that of pure invasive tumors and in tumors with greater than 0.5 ern of fibrosis or linear invasion. Using microarray gene expression profiling of human tumors, dysregulation of transforming growth factor-beta signaling was identified as an important mediator Of tumor invasion. Subsequent studies showed that the CC chemokine regulated on activation, normal T cell expressed, and presumably secreted was up-regulated in invasive tumors and was required for invasion in cells with repressed levels of the transforming growth factor-beta type II receptor. Taken together, these studies illustrate how information gained from global expression profiling of tumors can be used to identify key pathways and genes mediating turner growth, invasion, and metastasis.
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