期刊
JOURNAL OF THORACIC ONCOLOGY
卷 3, 期 7, 页码 774-780出版社
ELSEVIER SCIENCE INC
DOI: 10.1097/JTO.0b013e31817c7439
关键词
breath test; volatile organic compounds; mass spectrometry; diagnostic test
Volatile organic compounds are able to be detected in the exhaled breath by a variety of sensing techniques. These volatiles may be produced by cellular metabolic processes, or inhaled/absorbed from exogenous sources. Lung cancer cells may produce and process these compounds different than normal cells. The differences may be detectable in the breath. The following manuscript will review the evidence supporting the premise that a unique chemical signature can be detected in the breath of patients with lung cancer, discuss the results of studies using mass spectrometry and nonspecific chemical sensing techniques to detect the unique lung cancer signature, and speculate on the advancements that must occur to develop a breath test accurate enough to be clinically useful.
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