4.7 Article

A Framework for Genetic Logic Synthesis

期刊

PROCEEDINGS OF THE IEEE
卷 103, 期 11, 页码 2196-2207

出版社

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JPROC.2015.2443832

关键词

Boolean; digital; genetic; logic; synthesis; synthetic biology; transcription

资金

  1. National Science Foundation [1147158, 1253856]
  2. Air Force Academy Faculty Pipeline Fellowship
  3. Office of Naval Research (ONR) [N00014-13-1-0074]
  4. National Institutes of Health [GMO98792]
  5. National Science Foundation Synthetic Biology Engineering Research Center (SynBERC) [EEC0540879]
  6. Direct For Biological Sciences
  7. Div Of Biological Infrastructure [1147158] Funding Source: National Science Foundation
  8. Direct For Biological Sciences
  9. Div Of Molecular and Cellular Bioscience [1253856] Funding Source: National Science Foundation

向作者/读者索取更多资源

Digital electronic circuits have inspired synthetic biologists to program living cells with synthetic decision-making circuits by creating multilevel genetic logic gates. In both genetic and electronic circuits, logic synthesis translates an abstract functional description into a representation that can be physically implemented. However, inherent differences in genetic logic devices present new synthesis challenges. Here we provide a starting point for a growing set of biodesign automation tools to tackle this challenge in a unified way. This framework will enable direct comparison of new approaches, results that are transferable and standardized, and research into independent areas of the problem formulation with a clear path toward future integration.

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