期刊
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
卷 115, 期 3, 页码 2457-2461出版社
SPRINGER
DOI: 10.1007/s10973-013-3380-0
关键词
DA-6034; Crystal form; DSC; PXRD; TG; Dissolution
资金
- Duksung Women's University
DA-6034 is a new synthetic flavonoid known to possess anti-inflammatory activity. The objective of this work was to investigate the existence of polymorphs and pseudopolymorphs of DA-6034. Six crystal forms, one hydrate form and five solvates, of DA-6034 have been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TG), and powder X-ray diffractometry (PXRD). From the DSC and TG data it was confirmed that Form 1 is monohydrate; Form 2 is DMSO solvate; Form 3 is 1/2 DMSO solvate; Form 4 is 1/2 methyl ethyl ketone solvate; Form 5 is 1.5 H2O, 1/2 acetic acid solvate; Form 6 is 1/2 H2O, 1/4 butanol solvate. The PXRD patterns of the six crystal forms were different respectively. In the dissolution studies in pH 6.8 +/- A 0.05 buffer at 37 +/- A 0.5 A degrees C, the solubility of solvates was higher than that of Form 1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据