期刊
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
卷 108, 期 1, 页码 53-57出版社
SPRINGER
DOI: 10.1007/s10973-011-1424-x
关键词
Nevirapine; Differential scanning calorimetry (DSC); Thermogravimetry differential thermal analysis (TG-DTA); Solid dosage forms
资金
- FAPESP (Fundacao de Amparo a Pesquisa)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.
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