期刊
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
卷 99, 期 2, 页码 631-637出版社
SPRINGER
DOI: 10.1007/s10973-009-0351-6
关键词
Compatibility study; Differential scanning calorimetry; Lipoic acid; HPLC; IR
资金
- UBA [B116/2004-2008]
Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of lipoic acid with some currently employed cosmetic excipients. In the first phase of the study DSC was used as a tool to detect any interaction. Based on the DSC results alone, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butylated hydroxytoluene, non ionic self emulsifying wax, propylene glycol and acetylated lanolin were found to exhibit interaction with lipoic acid. Stressed binary mixtures (stored at 50 degrees C for 1 week) of lipoic acid and excipients were evaluated by HPLC. Binary mixtures were evaluated by IR spectroscopy.
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