期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 456, 期 -, 页码 62-73出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2018.07.029
关键词
Respiratory syncytial virus; Fusion inhibitors; African green monkey; Mathematical modelling; Drug efficacy
资金
- Janssen Research and Development Belgium
- Janssen RD Belgium [610765]
Respiratory syncytial virus (RSV) is a respiratory infection that can cause serious illness, particularly in infants. In this study, we test four different model implementations for the effect of a fusion inhibitor, including one model that combines different drug effects, by fitting the models to data from a study of TMC353121 in African green monkeys. We use mathematical modeling to estimate the drug efficacy parameters, epsilon(max), the maximum efficacy of the drug, and EC50, the drug concentration needed to achieve half the maximum effect. We find that if TMC353121 is having multiple effects on viral kinetics, more detailed data, using different treatment delays, is needed to detect this effect. (C) 2018 Elsevier Ltd. All rights reserved.
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