期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 306, 期 -, 页码 73-92出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2012.04.018
关键词
Mycoplasma gallisepticum; House finch (Carpodacus mexicanus); Immune response; Virulence; Ordinary differential equations
资金
- NSF DEB [0622705]
- Alfred P. Sloan Foundation
- Cornell University Graduate School
- Center for Applied Mathematics at Cornell
- Mathematical Biosciences Institute at The Ohio State University (NSF DMS) [0635561, 0931642]
- Direct For Biological Sciences
- Division Of Environmental Biology [0622705] Funding Source: National Science Foundation
The host-pathogen interaction drives infectious disease dynamics at the individual, population and community levels. Here I present and analyze a model of the vertebrate immune response to mycoplasma infections, and use it to identify which pathogen and host immune characteristics drive patterns of Mycoplasma gallisepticum (MG) infections in the house finch (Carpodacus mexicanus) and other passerine birds. I also address which host and pathogen characteristics most affect host infectiousness and survival. These results imply that much of the observed variation in the house finch likely arises from variation among birds in the effectiveness of their non-specific immune response to MG, and that the host and pathogen characteristics most likely to influence host infectiousness and survival are the intrinsic pathogen growth rate, the strength and efficiency of the non-specific immune response and characteristics affecting the effectiveness of the specific response. These findings suggest that molecular-level study of how MG and other mycoplasmas interact with a host's non-specific and inflammatory responses should reveal much about the relationships between host infectiousness, pathogen load, and disease symptoms in these systems. (C) 2012 Elsevier Ltd. All rights reserved.
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