期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 266, 期 1, 页码 117-123出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2010.06.021
关键词
Skeletal muscle; Eccentric contraction; Muscle model; Simulation
资金
- DFG (Deutsche Forschungsgemeinschaft, Germany) [SI 841/2-2, SI 841/2-3]
Based on previous experimental results of independence on starting length of the tension gradient in constant-velocity stretches of active skeletal muscle at muscle lengths including the ascending limb and the plateau of the tension-length relation, a possible physiological mechanism determining the tension increase in lengthening active muscle is discussed. Considering the sliding filament theory, it is suggested that the tension-length relation of a half-sarcomere in lengthening contractions is different from that in isometric contractions. The assumed mechanism predicts, among others, that the thick filament retains its shortened length in lengthening contractions starting from a half-sarcomere length where this filament is compressed. An example model is implemented and checked with simulations. (C) 2010 Elsevier Ltd. All rights reserved.
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