期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 259, 期 1, 页码 24-30出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2009.03.023
关键词
Single cell; Lag time; Stochastic process; Parameter estimation; Probability distribution
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/F/00042266] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/E/F/00042266] Funding Source: researchfish
In Quantitative Microbial Risk Assessment, it is vital to understand how lag times of individual cells are distributed over a bacterial population. Such identified distributions can be used to predict the time by which, in a growth-supporting environment, a few pathogenic cells can multiply to a poisoning concentration level. We model the lag time of a single cell, inoculated into a new environment, by the delay of the growth function characterizing the generated subpopulation. We introduce an easy-to-implement procedure, based on the method of moments, to estimate the parameters of the distribution of single cell lag times. The advantage of the method is especially apparent for cases where the initial number of cells is small and random, and the culture is detectable only in the exponential growth phase. (C) 2009 Elsevier Ltd. All rights reserved.
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