期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 253, 期 4, 页码 749-754出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2008.04.021
关键词
impulsive differential equations; infection age; impulsive period; drug-treatment proportion; infection-free state
In this paper, we develop an HIV model that considers the dependence of HIV/AIDS progress on infection age (duration since infection), chronological age and impulsive antiretroviral treatment. The analytical results show that there exists a globally asymptotically stable infection-free state when the impulsive period T and drug-treatment proportion p satisfy R-0(p,T) < 1. The numerical simulation results indicate that there exist T and p such that R-0(p, T) < 1. Due to pulses, it would be difficult to obtain the optimal pulse interval in the age distribution of population. However, our results demonstrate the effect of the impulsive drug-treatment strategy on the dynamics of HIV/AIDS. (C) 2008 Elsevier Ltd. All rights reserved.
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