期刊
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
卷 93, 期 6, 页码 1310-1316出版社
WILEY
DOI: 10.1002/jsfa.5887
关键词
Fuzhuan brick tea water extract; anti-obesity; hypolipidemic; hepatic steatosis
资金
- Key Project of Hunan Provincial Department of Science and Technology [2008FJ1005]
- National Natural Science Foundation of China [31200522]
- Ministry of Science and Technology of China
- Key Project of National Technology Innovation System for Tea Industry in the People's Republic of China [CARS-23]
Background Fuzhuan brick tea is a kind of microbial fermented tea, which has received increasing attention in recent years owing to its benefits for human health. In this study, the anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extracts (FTEs) were investigated. Results FTEs consisted of 204.07 +/- 3.38 mg g1 polyphenol, 109.20 +/- 1.36 mg g1 flavonoids, and others. The FTEs significantly suppressed the increase of body weight and accumulation of adipose tissue, and reduced the level of serum triacylglycerol, total cholesterol and low-density lipoprotein (LDL) cholesterol in obese rats fed a high-fat diet. Moreover, FTEs attenuated the gene expression of sterol regulatory element binding protein-1c, fatty acid synthase and CCAAT/enhancer binding protein , which is related to lipogenic metabolism. In contrast, the gene expressions of enzymes involved in energy expenditure and lipodieresis including hepatic peroxisome proliferator-activated receptor , carnitine palmitoyltransferase 1a and LDL receptor gene expression were increased by FTE treatment. Conclusions Our study demonstrates that FTEs have anti-obesity and hypolipidemic functions, suggesting that it might be effective for treatment of obesity and hyperlipemia. (C) 2012 Society of Chemical Industry
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据