期刊
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
卷 63, 期 3, 页码 499-514出版社
WILEY-BLACKWELL
DOI: 10.1111/rssc.12043
关键词
Partial area under the curve; Receiver operating characteristic curve; Area under the curve; Power; Two-stage design; Diagnostic accuracy
资金
- National Cancer Institute [R15CA150698]
- National Security Agency [H98230-11-1-0196]
A subjective sampling ratio between the case and the control groups is not always an efficient choice to maximize the power or to minimize the total required sample size in comparative diagnostic trials. We derive explicit expressions for an optimal sampling ratio based on a common variance structure shared by several existing summary statistics of the receiver operating characteristic curve. We propose a two-stage procedure to estimate adaptively the optimal ratio without pilot data. We investigate the properties of the proposed method through theoretical proofs, extensive simulation studies and a real example in cancer diagnostic studies.
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