期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 11, 期 101, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2014.0873
关键词
brain functional networks; fMRI; persistent homology; psilocybin
资金
- TOPDRIM project by the Future and Emerging Technologies programme of the European Commission [IST-318121]
- PET methodology programme grant from the Medical Research Council UK [G1100809/1]
- Beckley Foundation
- MRC [G1100809] Funding Source: UKRI
- Medical Research Council [G1100809, 1110783] Funding Source: researchfish
Networks, as efficient representations of complex systems, have appealed to scientists for a long time and now permeate many areas of science, including neuroimaging (Bullmore and Sporns 2009 Nat. Rev. Neurosci. 10, 186-198. (doi: 10.1038/nrn2618)). Traditionally, the structure of complex networks has been studied through their statistical properties and metrics concerned with node and link properties, e.g. degree-distribution, node centrality and modularity. Here, we study the characteristics of functional brain networks at the mesoscopic level from a novel perspective that highlights the role of inhomogeneities in the fabric of functional connections. This can be done by focusing on the features of a set of topological objects-homological cycles-associated with the weighted functional network. We leverage the detected topological information to define the homological scaffolds, a new set of objects designed to represent compactly the homological features of the correlation network and simultaneously make their homological properties amenable to networks theoretical methods. As a proof of principle, we apply these tools to compare resting state functional brain activity in 15 healthy volunteers after intravenous infusion of placebo and psilocybin-the main psychoactive component of magic mushrooms. The results show that the homological structure of the brain's functional patterns undergoes a dramatic change post-psilocybin, characterized by the appearance of many transient structures of low stability and of a small number of persistent ones that are not observed in the case of placebo.
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